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Article

Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression.

The EMBO journal - 7 Jun 2006

Chao Connie, Herr Deron, Chun Jerold, Xu Yang

Abstract excerpt

Mouse p53 is phosphorylated at Ser18 and Ser23 after DNA damage. To determine whether these two phosphorylation events have synergistic functions in activating p53 responses, we simultaneously introduced Ser18/23 to Ala mutations into the endogenous p53 locus in mice. While partial defects in apo...

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Share to Apoptosis
Share to DNA Damage
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphorylation

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Share to Thymus Gland

Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 16757976
DOI: 10.1038/sj.emboj.7601167
PMCID: PMC1478190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16757976-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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