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Article

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.

The Journal of cell biology - 1 Dec 2008

Daniel Jeremy A, Pellegrini Manuela, Lee Ji-Hoon, Paull Tanya T, Feigenbaum Lionel, Nussenzweig André

Abstract excerpt

Cellular responses to both physiological and pathological DNA double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (ATM) kinase. Upon DNA damage, an activation mechanism involving autophosphorylation has been reported to allow ATM to phosphorylate downstream targets important for cell cycle checkpoints and DNA repair. In humans, serine residues 367,...

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Share to Ataxia Telangiectasia Mutated Proteins
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19047460
DOI: 10.1083/jcb.200805154
PMCID: PMC2592823

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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