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Article

Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage.

PloS one - 1 Jan 2016

Langlands Hannah, Blain Peter G, Jowsey Paul A

Abstract excerpt

Fe65 undergoes a phosphatase-sensitive gel mobility shift after DNA damage, consistent with protein phosphorylation. A recent study identified Ser228 as a specific site of phosphorylation, targeted by the ATM and ATR protein kinases, with phosphorylation inhibiting the Fe65-dependent transcriptional activity of the amyloid precursor protein (APP). The direct binding of Fe65 to APP not only regulates target gene...

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Source

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Identifiers

PMID: 27176072
DOI: 10.1371/journal.pone.0155056
PMCID: PMC4866770

Genes

APP
ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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