Specific DNA binding by p53 is independent of mutation at serine 389, the casein kinase II site.

Article

Specific DNA binding by p53 is independent of mutation at serine 389, the casein kinase II site.

Oncogene - 1 Oct 1994

Rolley N, Milner J

Abstract excerpt

The best understood function of p53 is that of cell growth suppression and this is likely to involve sequence-specific DNA binding and modulation of gene expression. Casein kinase II phosphorylates the C-terminal serine of p53 (residue 389 for murine p53) and mutation of this site abolishes p53 g...

Topics

Animals
Base Sequence
Casein Kinase II
DNA
Mice
Molecular Sequence Data
Mutation
Phosphorylation
Protein Serine-Threonine Kinases
Serine
Tumor Suppressor Protein p53

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