Article
Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas.
Cancer research - 1 May 2005
Hoogervorst Esther M, Bruins Wendy, Zwart Edwin, van Oostrom Conny Th M, van den Aardweg Gerard J, Beems Rudolf B, van den Berg Jolanda, Jacks Tyler, van Steeg Harry, de Vries Annemieke
Abstract excerpt
Cellular activity of the tumor suppressor protein p53 is primarily regulated by posttranslational modifications. Phosphorylation of the COOH terminus, including Ser389, is thought to result in a conformational change of the p53 protein, enhancing DNA binding and transcriptional activity. In vitro studies presented here show that, in addition to UV radiation, Ser389 is phosphorylated upon exposure to...
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