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Article

Requirement for phosphorylation of P53 at Ser312 in suppression of chemical carcinogenesis.

Scientific reports - 31 Oct 2013

Slee Elizabeth A, Lu Xin

Abstract excerpt

The p53 tumour suppressor is activated in response to a wide variety of genotoxic stresses, frequently via post-translational modification. Using a knock in mouse model with a Ser312 to Ala mutation, we show here that phosphorylation of p53 on Ser312 helps to prevent tumour induction by the alkylating agent MNU, which predominantly caused T cell lymphomas. This is consistent with our previous observation that...

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Identifiers

PMID: 24173284
DOI: 10.1038/srep03105
PMCID: PMC3813944

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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