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Article

Ser392 phosphorylation regulates the oncogenic function of mutant p53.

Cancer research - 15 Jul 2004

Yap Damian B S, Hsieh Jung-Kuang, Zhong Shan, Heath Vicky, Gusterson Barry, Crook Tim, Lu Xin

Abstract excerpt

Despite the wealth of information on the regulation of wild-type p53 function by phosphorylation, nothing is known about the biological effect of phosphorylation on mutant p53. Here we show that p53H175 is phosphorylated like wild-type p53 in cells of the same background. Ser(392) nonphosphorylatable p53 mutants p53H175A392 and p53W248A392 more potently transformed rat embryo fibroblasts in cooperation with the...

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Identifiers

PMID: 15256442
DOI: 10.1158/0008-5472.CAN-1305-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ser392 phosphorylation regulates the oncogenic function of mutant p53.PMID 15256442Read ↗

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