Article
Generation of novel conditional and hypomorphic alleles of the Smad2 gene.
Genesis (New York, N.Y. : 2000) - 1 Oct 2004
Liu Ye, Festing Maria H, Hester Mark, Thompson John C, Weinstein Michael
Abstract excerpt
Smad2 is an intracellular mediator of the transforming growth factor beta signaling (TGFbeta) pathway. It has been previously shown that, in the mouse, ablation of functional Smad2 results in embryonic lethality due to gastrulation defects. To circumvent the early lethality and study the spatially and temporally specific functions of Smad2, we utilized the Cre-loxP system to generate a Smad2 conditional allele....
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