Article
Generation of mice with a conditional null allele of the Jagged2 gene.
Genesis (New York, N.Y. : 2000) - 1 Jun 2010
Xu Jingxia, Krebs Luke T, Gridley Thomas
Abstract excerpt
The Notch signaling pathway is an evolutionarily-conserved intercellular signaling mechanism, and mutations in its components disrupt embryonic development in many organisms and cause inherited diseases in humans. The Jagged2 (Jag2) gene, which encodes a ligand for Notch pathway receptors, is required for craniofacial, limb, and T cell development. Mice homozygous for a Jag2 null allele die at birth from cleft...
Topics
- Animals
- Blotting, Southern
- Cleft Palate
- Craniofacial Abnormalities
- Embryo, Mammalian
- Female
- Genes, Lethal
- Homozygote
- In Situ Hybridization
- Integrases
- Jagged-2 Protein
- Limb Deformities, Congenital
- Male
- Membrane Proteins
- Mice
- Mice, Knockout
- Phenotype