Article
Generation and functional characterization of mice with a conditional BMP7 allele.
The International journal of developmental biology - 1 Jan 2009
Zouvelou Vasiliki, Passa Ourania, Segklia Katerina, Tsalavos Sotiris, Valenzuela David M, Economides Aris N, Graf Daniel
Abstract excerpt
Bone Morphogenetic Proteins (BMPs) play multiple and important roles in embryonic development as well as in homeostasis and tissue repair in the adult. Bmp7 has been implicated in developmental disorders and in a variety of diseases, but functional studies to elucidate its role so far have been hampered, since mice deficient in BMP7 die around or just after birth. To facilitate such studies, we generated mice in...
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