Article
TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.
Development (Cambridge, England) - 1 Jul 1997
Sanford L P, Ormsby I, Gittenberger-de Groot A C, Sariola H, Friedman R, Boivin G P, Cardell E L, Doetschman T
Abstract excerpt
The growth and differentiation factor transforming growth factor-beta2 (TGFbeta2) is thought to play important roles in multiple developmental processes. Targeted disruption of the TGFbeta2 gene was undertaken to determine its essential role in vivo. TGFbeta2-null mice exhibit perinatal mortality...
Topics
- Abnormalities, Multiple
- Animals
- Bone and Bones
- Cleft Palate
- Craniofacial Abnormalities
- Cyanosis
- Ear, Inner
- Embryonic Induction
- Epithelium
- Eye Abnormalities
- Genes, Homeobox