Article
Generation of an Frs2alpha conditional null allele.
Genesis (New York, N.Y. : 2000) - 1 Sept 2007
Lin Yongshun, Zhang Jue, Zhang Yongyou, Wang Fen
Abstract excerpt
The fibroblast growth factor (FGF) signaling family controls a broad spectrum of cellular processes in development and adult tissue homeostasis and function, which is expressed in almost all tissues at all stages. FGF receptor substrate 2 alpha (FRS2alpha) is an adaptor protein that recruits downstream substrates to the FGF receptor (FGFR) tyrosine kinase. Disruption of Frs2alpha gene in mice abrogates activation...
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