Article
Generation of mice with a conditional null allele for Tbx2.
Genesis (New York, N.Y. : 2000) - 1 Mar 2010
Wakker Vincent, Brons Janynke F, Aanhaanen Wim T J, van Roon Marian A, Moorman Antoon F M, Christoffels Vincent M
Abstract excerpt
The T-box transcription factor Tbx2 plays important roles in patterning and development, and has been implicated in cell-cycle regulation and cancer. Conventional disruption of Tbx2 results in abnormalities of the heart, limbs, eye and other structures, and early fetal lethality. To gain insight into the role of Tbx2 in different tissues and at different stages of development, we have generated a conditional null...
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