Article
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.
Cell - 20 Mar 1998
Waldrip W R, Bikoff E K, Hoodless P A, Wrana J L, Robertson E J
Abstract excerpt
Smad proteins transmit TGFbeta signals from the cell surface to the nucleus. Here we analyze Smad2 mutant embryos created using ES cell technology. Smad2 function is not required for mesoderm production per se, but, rather unexpectedly, in the absence of Smad2 the entire epiblast adopts a mesoder...
Topics
- Animals
- DNA-Binding Proteins
- Embryonic Development
- Embryonic and Fetal Development
- Female
- Gastrula
- Gene Expression Regulation, Developmental
- Genes, Reporter
- Genotype
- Lac Operon
- Mesoderm
- Mice
- Mice, Mutant Strains
- Mutagenesis
- Pregnancy
- Signal Transduction
- Smad2 Protein
- Trans-Activators