Article
Generation of a floxed allele of Smad5 for cre-mediated conditional knockout in the mouse.
Genesis (New York, N.Y. : 2000) - 1 Sept 2003
Umans Lieve, Vermeire Liesbeth, Francis Annick, Chang Hua, Huylebroeck Danny, Zwijsen An
Abstract excerpt
Smad5 is a member of the Smad family of intracellular mediators of BMP signals and in endothelial cells of TGF-beta signals. We and others previously showed that loss of Smad5 in the mouse results in embryonic lethality (between E9.5-E11.5) due to multiple embryonic and extraembryonic defects. To circumvent the early embryonic lethality and to allow tissue- and time-specific Smad5 inactivation, we created a...
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