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Article

Generation of new Notch2 mutant alleles.

Genesis (New York, N.Y. : 2000) - 1 Jan 2006

McCright Brent, Lozier Julie, Gridley Thomas

Abstract excerpt

The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism, and mutations in its components disrupt embryonic development in many organisms and cause inherited diseases in humans. We previously described construction and analysis of a hypomorphic allele of the Notch2 gene. Homozygosity for this allele leads to embryonic and perinatal lethality due to cardiovascular and kidney...

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Identifiers

PMID: 16397869
DOI: 10.1002/gene.20181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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