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Restoration of an absent G <sub>1</sub> arrest and protection from apoptosis in embryonic stem cells after ionizing radiation

27 Sept 2004

Abstract excerpt

Response to DNA damage and cell-cycle regulation differ markedly between embryonic stem (ES) cells and somatic cells. ES cells require exquisitely sensitive mechanisms to maintain genomic integrity and do so, in part, by suppressing spontaneous mutation. Spontaneous mutation frequency in somatic cells is approximately 10(-4) compared with 10(-6) for ES cells. ES cells also lack a G(1) checkpoint and are...

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PMID: 15452351
DOI: 10.1073/pnas.0401346101

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