Article

ATR enforcement of the S/G2 checkpoint prevents premature S phase shutdown and genome instability

2026-05-09

Abstract excerpt

The ATR-enforced S/G2 checkpoint activates during DNA replication to restrain CDK1-dependent phosphorylation of FOXM1 and subsequent transactivation of the G2/M gene network until the end of S phase. However, the extent to which this checkpoint ensures the completion of DNA replication and whether it safeguards genomic integrity has remained unknown. Here, we induce S/G2 checkpoint failure throughout S phase in no...

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Literature Corpus work: 66dcf394-04fa-5cba-9ade-f09be4a1ff18
DOI: 10.64898/2026.05.07.723638

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