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Human Embryonic Stem Cells Are Capable of Executing G1/S Checkpoint Activation

1 Jun 2010

Abstract excerpt

Embryonic stem cells progress very rapidly through the cell cycle, allowing limited time for cell cycle regulatory circuits that typically function in somatic cells. Mechanisms that inhibit cell cycle progression upon DNA damage are of particular importance, as their malfunction may contribute to the genetic instability observed in human embryonic stem cells (hESCs). In this study, we exposed undifferentiated...

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PMID: 20518019
DOI: 10.1002/stem.451

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