Article

ATRIP protects progenitor cells against DNA damage <i>in vivo</i>

2020-02-14

Abstract excerpt

The maintenance of genomic stability during the cell cycle of progenitor cells is essential for the faithful transmission of genetic information. Mutations in genes that ensure genome stability lead to human developmental syndromes. Mutations in Ataxia Telangiectasia and Rad3-related (ATR) or in ATR-interacting protein ( ATRIP ) lead to Seckel syndrome, which is characterized by developmental malformations and sh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d2c9ce8-c9f7-5653-a3a3-eb8af8a4935a
DOI: 10.1101/2020.02.14.948265

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

ATRIP protects progenitor cells against DNA damage <i>in vivo</i>DOI 10.1101/2020.02.14.948265Read

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.Semantic proximity Read

ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.Semantic proximity Read

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.Semantic proximity Read

Stalled replication forks within heterochromatin require ATRX for protectionSemantic proximity Read

ATR disruption leads to chromosomal fragmentation and early embryonic lethality.Semantic proximity Read

ATR localizes to the photoreceptor connecting cilium and deficiency leads to severe photoreceptor degeneration in mice.Semantic proximity Read

ATR signalling: more than meeting at the forkSemantic proximity Read

Genome maintenance during embryogenesis.Semantic proximity Read

Specialized Circuitry of Embryonic Stem Cells Promotes Genomic Integrity.Semantic proximity Read

ATRIP deficiency impairs the replication stress response and manifests as microcephalic primordial dwarfism and immunodeficiencySemantic proximity Read

Replication stress, microcephalic primordial dwarfism, and compromised immunity in ATRIP deficient patientsSemantic proximity Read

Restoration of an absent G <sub>1</sub> arrest and protection from apoptosis in embryonic stem cells after ionizing radiationSemantic proximity Read