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Human embryonic stem cells fail to activate CHK1 and commit to apoptosis in response to DNA replication stress.

Stem cells (Dayton, Ohio) - 1 Jul 2012

Desmarais Joëlle A, Hoffmann Michele J, Bingham Gregg, Gagou Mary E, Meuth Mark, Andrews Peter W

Abstract excerpt

Pluripotent cells of the early embryo, to which embryonic stem cells (ESCs) correspond, give rise to all the somatic cells of the developing fetus. Any defects that occur in their genome or epigenome would have devastating consequences. Genetic and epigenetic change in human ESCs appear to be an inevitable consequence of long-term culture, driven by selection of variant cells that have a higher propensity for...

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PMID: 22553144
DOI: 10.1002/stem.1117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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