Article
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.
Current biology : CB - 20 Apr 2000
de Klein A, Muijtjens M, van Os R, Verhoeven Y, Smit B, Carr A M, Lehmann A R, Hoeijmakers J H
Abstract excerpt
Checkpoints of DNA integrity are conserved throughout evolution, as are the kinases ATM (Ataxia Telangiectasia mutated) and ATR (Ataxia- and Rad-related), which are related to phosphatidylinositol (PI) 3-kinase [1] [2] [3]. The ATM gene is not essential, but mutations lead to ataxia telangiectasi...
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