Article

Poliovirus tropism and attenuation are determined after internal ribosome entry

2004-06-15

Abstract excerpt

Poliovirus replication is limited to a few organs, including the brain and spinal cord. This restricted tropism may be a consequence of organ-specific differences in translation initiation by the poliovirus internal ribosome entry site (IRES). A C-to-U mutation at base 472 in the IRES of the Sabin type 3 poliovirus vaccine strain, known to attenuate neurovirulence, may further restrict tropism by eliminating viral...

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Literature Corpus work: 122dac9a-38f1-5c61-a194-d6ef3823d534
DOI: 10.1172/jci200421323

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