Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.

doi:10.1073/pnas.93.6.2370

Article

Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants.

19 Mar 1996

Abstract excerpt

Neuropathogenicity of poliovirus can be attenuated by mutations in the internal ribosomal entry site (IRES) within the 5' nontranslated region of its genome. The Sabin vaccine strains used in prevention of poliomyelitis carry such mutations in their IRES elements. In addition, mutations within the structural and nonstructural proteins of Sabin strains may equally contribute to the attenuation phenotype. Despite...

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