Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.

doi:10.1128/JVI.71.5.3826-3833.1997

Back to search

Article

Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.

Journal of virology - 1 May 1997

Gutiérrez A L, Denova-Ocampo M, Racaniello V R, del Angel R M

Abstract excerpt

Mutations in the 5' untranslated regions (5'-UTRs) of all three serotypes of the Sabin vaccine strains are known to be major determinants of the attenuation phenotype. To further understand the functional basis of the attenuation phenotype caused by mutations in the 5'-UTR, we studied their effec...

Topics

HeLa Cells
Humans
Mutation
Phenotype
Poliovirus
Polypyrimidine Tract-Binding Protein
Protein Biosynthesis
RNA, Viral
RNA-Binding Proteins
Ribonucleoproteins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.