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Article

Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.

Journal of virology - 1 May 1997

Gutiérrez A L, Denova-Ocampo M, Racaniello V R, del Angel R M

Abstract excerpt

Mutations in the 5' untranslated regions (5'-UTRs) of all three serotypes of the Sabin vaccine strains are known to be major determinants of the attenuation phenotype. To further understand the functional basis of the attenuation phenotype caused by mutations in the 5'-UTR, we studied their effects on viral replication, translation, and the interaction of the viral RNA with cell proteins. A mutation at base 472...

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Identifiers

PMID: 9094658
DOI: 10.1128/JVI.71.5.3826-3833.1997
PMCID: PMC191533

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Attenuating mutations in the poliovirus 5' untranslated region alter its interaction with polypyrimidine tract-binding protein.PMID 9094658Read ↗

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