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Article

Increased cytotoxic potential of microglia from ALS-transgenic mice.

Glia - 1 Nov 2004

Weydt Patrick, Yuen Eric C, Ransom Bruce R, Möller Thomas

Abstract excerpt

Amyotrophic lateral sclerosis is a fatal, adult-onset motor neuron disease. A subset of cases is caused by mutations of superoxide dismutase 1 (SOD1) gene. The mechanisms how the mutations in this ubiquitous enzyme mediate the highly selective motor neuron degeneration, however, remain poorly understood. Recent results from transgenic animal models suggest a "non-cell autonomous" mechanism; i.e., cells other than...

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Source

Identifiers

PMID: 15378658
DOI: 10.1002/glia.20062

Genes

SOD1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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