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Article

Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia.

Journal of neurochemistry - 1 Sept 2007

Xiao Qin, Zhao Weihua, Beers David R, Yen Albert A, Xie Wenjie, Henkel Jenny S, Appel Stanley H

Abstract excerpt

Recent studies suggest that microglia over-expressing mutant human superoxide dismutase (mSOD1(G93A)) may contribute to motoneuron death in a transgenic mouse model of familial amyotrophic lateral sclerosis. To further assess the relative neurotoxicity of wild-type microglia, mSOD1(G93A) microglia, and microglia over-expressing wild-type human SOD1, we used primary cultures of microglia and motoneurons in the...

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Source

Identifiers

PMID: 17555556
DOI: 10.1111/j.1471-4159.2007.04677.x

Genes

SOD1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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