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Article

Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.

Experimental neurology - 1 Dec 2009

Gowing Genevieve, Lalancette-Hébert Mélanie, Audet Jean-Nicolas, Dequen Florence, Julien Jean-Pierre

Abstract excerpt

Macrophage colony stimulating factor (M-CSF) is a cytokine that regulates the survival, proliferation and maturation of microglial cells. Administration of M-CSF can promote neuronal survival in various models of central nervous system (CNS) injury. Here, in an attempt to induce a neuroprotective...

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Source

Identifiers

PMID: 19733170
DOI: 10.1016/j.expneurol.2009.08.021

Genes

SOD1
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19733170-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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