Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1.

Neuroreport - 28 Oct 2009

Sargsyan Siranush A, Blackburn Daniel J, Barber Siân C, Monk Peter N, Shaw Pamela J

Abstract excerpt

The inflammatory response in amyotrophic lateral sclerosis (ALS) is well documented but the underlying cellular mechanisms have not been fully elucidated. We report that microglia isolated from the mutant human superoxide dismutase 1 (SOD1) G93A transgenic mouse model of ALS have an increased response to the inflammatory stimulus, lipopolysaccharide. Cell surface area and F4/80 surface marker, both indicators of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Chemokine CCL2
Share to Culture Media, Conditioned

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dinoprostone

Share to Enzyme-Linked Immunosorbent Assay

Share to Lipopolysaccharides

Share to Microglia

Share to Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 19752764
DOI: 10.1097/WNR.0b013e328331e8fa
PMCID: PMC2889291

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutant SOD1 G93A microglia have an inflammatory phenotype and elevated production of MCP-1.PMID 19752764Read ↗

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse ModelSemantic proximity Read ↗

Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats.Semantic proximity Read ↗

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.Semantic proximity Read ↗

Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia.Semantic proximity Read ↗

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS.Semantic proximity Read ↗

Increased activation ability of monocytes from ALS patients.Semantic proximity Read ↗

A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function.Semantic proximity Read ↗

Expression of Amyotrophic Lateral Sclerosis-linked SOD1 Mutant Increases the Neurotoxic Potential of Microglia via TLR2Semantic proximity Read ↗

Macrophage colony stimulating factor (M-CSF) exacerbates ALS disease in a mouse model through altered responses of microglia expressing mutant superoxide dismutase.Semantic proximity Read ↗

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1.Semantic proximity Read ↗

Defective phagocytic function of induced microglia-like cells is correlated with rapid progression of sporadic ALSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.