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Article

A comparison of in vitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function.

BMC neuroscience - 23 Sept 2011

Sargsyan Siranush A, Blackburn Daniel J, Barber Siân C, Grosskreutz Julian, De Vos Kurt J, Monk Peter N, Shaw Pamela J

Abstract excerpt

BACKGROUND: Overexpression of mutant copper/zinc superoxide dismutase (SOD1) in rodents has provided useful models for studying the pathogenesis of amyotrophic lateral sclerosis (ALS). Microglia have been shown to contribute to ALS disease progression in these models, although the mechanism of this contribution remains to be elucidated. Here, we present the first evidence of the effects of overexpression of...

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Identifiers

PMID: 21943126
DOI: 10.1186/1471-2202-12-91
PMCID: PMC3191510

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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