Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.

Journal of neurochemistry - 1 Jan 2002

Yoshihara Tsuyoshi, Ishigaki Shinsuke, Yamamoto Masahiko, Liang Yideng, Niwa Jun-ichi, Takeuchi Hideyuki, Doyu Manabu, Sobue Gen

Abstract excerpt

Familial amyotrophic lateral sclerosis (FALS)-linked mutations in copper-zinc superoxide dismutase (SOD1) cause motor neuron death through one or more acquired toxic properties. We analyzed the molecular mechanism underlying motor neuron degeneration in the transgenic mouse model expressing the S...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Apoptosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization

Share to Inflammation

Share to Oligonucleotide Array Sequence Analysis

Share to Spinal Cord

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 11796754
DOI: 10.1046/j.0022-3042.2001.00683.x

Genes

SOD1
TNF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11796754-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.PMID 11796754Read ↗

Transcriptional profiling in the lumbar spinal cord of a mouse model of amyotrophic lateral sclerosis: a role for wild-type superoxide dismutase 1 in sporadic disease?Semantic proximity Read ↗

Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords – screening by molecular indexing and subsequent cDNA microarray analysisSemantic proximity Read ↗

Neuroinflammation and ALS: Transcriptomic Insights into Molecular Disease Mechanisms and Therapeutic TargetsSemantic proximity Read ↗

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.Semantic proximity Read ↗

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosisSemantic proximity Read ↗

Cytokine upregulation in a murine model of familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Early gene expression changes in spinal cord from SOD1G93A Amyotrophic Lateral Sclerosis animal modelSemantic proximity Read ↗

NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model.Semantic proximity Read ↗

Activation of the stress-activated MAP kinase, p38, but not JNK in cortical motor neurons during early presymptomatic stages of amyotrophic lateral sclerosis in transgenic mice.Semantic proximity Read ↗

Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammationSemantic proximity Read ↗

Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.