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Article

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS.

Proceedings of the National Academy of Sciences of the United States of America - 18 Nov 2008

Chiu Isaac M, Chen Adam, Zheng Yi, Kosaras Bela, Tsiftsoglou Stefanos A, Vartanian Timothy K, Brown Robert H, Carroll Michael C

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is an adult-onset, progressive, motor neuron degenerative disease, in which the role of inflammation is not well established. Innate and adaptive immunity were investigated in the CNS of the Superoxide Dismutase 1 (SOD1)(G93A) transgenic mouse model of ALS. CD4+ and CD8+ T cells infiltrated SOD1(G93A) spinal cords during disease progression. Cell-specific flow cytometry and...

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Identifiers

PMID: 18997009
DOI: 10.1073/pnas.0804610105
PMCID: PMC2581614

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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