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Article

Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP.

The Journal of clinical investigation - 1 Sept 2004

Fujino Takayuki, Nakagawa Naoki, Yuhki Koh-Ichi, Hara Akiyoshi, Yamada Takehiro, Takayama Koji, Kuriyama Shuhko, Hosoki Yayoi, Takahata Osamu, Taniguchi Takanobu, Fukuzawa Jun, Hasebe Naoyuki, Kikuchi Kenjiro, Narumiya Shuh, Ushikubi Fumitaka

Abstract excerpt

Persistent reduction of renal perfusion pressure induces renovascular hypertension by activating the renin-angiotensin-aldosterone system; however, the sensing mechanism remains elusive. Here we investigated the role of PGI2 in renovascular hypertension in vivo, employing mice lacking the PGI2 receptor (IP-/- mice). In WT mice with a two-kidney, one-clip model of renovascular hypertension, the BP was...

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Identifiers

PMID: 15372104
DOI: 10.1172/JCI21382
PMCID: PMC516260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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