Article
Genetic deletion of COX-2 prevents increased renin expression in response to ACE inhibition.
American journal of physiology. Renal physiology - 1 Mar 2001
Cheng H F, Wang J L, Zhang M Z, Wang S W, McKanna J A, Harris R C
Abstract excerpt
Cyclooxygenase-2 (COX-2) is expressed in macula densa (MD) and surrounding cortical thick ascending limb of the loop of Henle (cTALH) and is involved in regulation of renin production. We and others have previously found that selective COX-2 inhibitors can inhibit renal renin production (Cheng HF, Wang JL, Zhang MZ, Miyazaki Y, Ichikawa I, McKanna JA, and Harris RC. J Clin Invest 103: 953-961, 1999; Harding P,...
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