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Article

Genetic deficiency of Smad3 protects the kidneys from atrophy and interstitial fibrosis in 2K1C hypertension.

American journal of physiology. Renal physiology - 1 Jun 2012

Warner Gina M, Cheng Jingfei, Knudsen Bruce E, Gray Catherine E, Deibel Ansgar, Juskewitch Justin E, Lerman Lilach O, Textor Stephen C, Nath Karl A, Grande Joseph P

Abstract excerpt

Although the two-kidney, one-clip (2K1C) model is widely used as a model of human renovascular hypertension, mechanisms leading to the development of fibrosis and atrophy in the cuffed kidney and compensatory hyperplasia in the contralateral kidney have not been defined. Based on the well-established role of the transforming growth factor (TGF)-β signaling pathway in renal fibrosis, we tested the hypothesis that...

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Source

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Identifiers

PMID: 22378822
DOI: 10.1152/ajprenal.00645.2011
PMCID: PMC3378173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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