Article
Elevated blood pressures in mice lacking endothelial nitric oxide synthase.
Proceedings of the National Academy of Sciences of the United States of America - 12 Nov 1996
Shesely E G, Maeda N, Kim H S, Desai K M, Krege J H, Laubach V E, Sherman P A, Sessa W C, Smithies O
Abstract excerpt
Nitric oxide produced in endothelial cells affects vascular tone. To investigate the role of endothelial nitric oxide synthase (eNOS) in blood pressure regulation, we have generated mice heterozygous (+/-) or homozygous (-/-) for disruption of the eNOS gene. Immunohistochemical staining with anti...
Topics
- Analysis of Variance
- Animals
- Blood Pressure
- Cattle
- Chimera
- DNA Primers
- Endothelium, Vascular
- Female
- Genotype
- Heterozygote
- Hypertension
- Isoenzymes
- Kidney
- Lipopolysaccharides
- Male
- Mice