Article
Identification of specific EP receptors responsible for the hemodynamic effects of PGE2.
The American journal of physiology - 1 Sept 1999
Audoly L P, Tilley S L, Goulet J, Key M, Nguyen M, Stock J L, McNeish J D, Koller B H, Coffman T M
Abstract excerpt
To identify the E-prostanoid (EP) receptors that mediate the hemodynamic actions of PGE2, we studied acute vascular responses to infusions of PGE2 using lines of mice in which each of four EP receptors (EP1 through EP4) have been disrupted by gene targeting. In mixed groups of males and females, vasodepressor responses after infusions of PGE2 were significantly diminished in the EP2 -/- and EP4 -/- lines but not...
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