Article
Cardiovascular and renal phenotype in mice with one or two renin genes.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2004
Lum Craig, Shesely Edward G, Potter D'Anna L, Beierwaltes William H
Abstract excerpt
We compared the phenotype of two common mouse models, C-57BL/6J (C57), which carries only the Ren-1c gene, and 129/SvJ (Sv-129), with both Ren 1d and Ren-2. We hypothesized two renin gene Sv-129 would have increased blood pressure and the renin-angiotensin system would be more influential in regulating renal function compared with one renin gene mice. Sv-129 consistently had higher blood pressure than C-57,...
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