Article

Intrarenal Generation of Aldosterone Contributes to Ischemia-Induced Hypertension and Nephropathy in Mice

2025-08-27

Abstract excerpt

<h4>Background</h4> The past few years have witnessed a significant advancement in aldosterone (Aldo)-targeted therapies for the management of treatment-resistant hypertension and chronic kidney disease, which often exist in tandem. While Aldo is believed to predominantly originate from the adrenal glands, this study provides evidence to support the involvement of intrarenal Aldo biosynthesis in the pathogenesis...

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Literature Corpus work: a8106c70-9763-5ff2-be38-8e0947ee8fad
DOI: 10.1101/2025.08.24.671658

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