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Article

The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure.

The Journal of clinical investigation - 1 Feb 2001

Stock J L, Shinjo K, Burkhardt J, Roach M, Taniguchi K, Ishikawa T, Kim H S, Flannery P J, Coffman T M, McNeish J D, Audoly L P

Abstract excerpt

The lipid mediator prostaglandin E2 (PGE2) has diverse biological activity in a variety of tissues. Four different receptor subtypes (EP1-4) mediate these wide-ranging effects. The EP-receptor subtypes differ in tissue distribution, ligand-binding affinity, and coupling to intracellular signaling pathways. To identify the physiological roles for one of these receptors, the EP1 receptor, we generated EP1-deficient...

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Identifiers

PMID: 11160156
DOI: 10.1172/JCI6749
PMCID: PMC199184

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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