Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.

doi:10.1161/01.CIR.0000155238.70797.4E

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Article

Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.

Circulation - 15 Feb 2005

Scotland Ramona S, Madhani Melanie, Chauhan Sharmila, Moncada Salvador, Andresen Jørgen, Nilsson Holger, Hobbs Adrian J, Ahluwalia Amrita

Abstract excerpt

BACKGROUND: Endothelium-dependent dilatation is mediated by 3 principal vasodilators: nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor (EDHF). To determine the relative contribution of these factors in endothelium-dependent relaxation, we have generated mice in which the enzymes required for endothelial NO and PGI2 production, endothelial NO synthase (eNOS) and...

Topics

6-Ketoprostaglandin F1 alpha
Acetylcholine
Animals
Aorta
Blood Pressure
Bradykinin
Capillary Resistance
Cyclooxygenase 1
Dose-Response Relationship, Drug
Electrophysiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Endothelium, Vascular

Endothelium-Dependent Relaxing Factors

Female

Genotype

Male

Membrane Proteins

Mesenteric Arteries

Mice

Source

Open in PubMed

Identifiers

PMID: 15699263
DOI: 10.1161/01.CIR.0000155238.70797.4E

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