Article
Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo.
Circulation - 15 Feb 2005
Scotland Ramona S, Madhani Melanie, Chauhan Sharmila, Moncada Salvador, Andresen Jørgen, Nilsson Holger, Hobbs Adrian J, Ahluwalia Amrita
Abstract excerpt
BACKGROUND: Endothelium-dependent dilatation is mediated by 3 principal vasodilators: nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor (EDHF). To determine the relative contribution of these factors in endothelium-dependent relaxation, we have generated mice in which the enzymes required for endothelial NO and PGI2 production, endothelial NO synthase (eNOS) and...
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