Article

Sex dependent compensatory mechanisms to preserve blood pressure homeostasis in PGI <sub>2</sub> receptor deficient mice

2020-01-28

Abstract excerpt

Inhibitors of microsomal prostaglandin E synthase-1 (mPges-1) are in the early phase of clinical development. Deletion of mPges-1 confers analgesia, restrains atherogenesis and fails to accelerate thrombogenesis, while suppressing prostaglandin (PG) E 2 , but increasing biosynthesis of prostacyclin (PGI 2 ). In hyperlipidemic mice, this last effect represents the dominant mechanism by which mPges-1 deletion rest...

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Literature Corpus work: dfaf7584-7b6c-5920-949c-3c1d91ee34c7
DOI: 10.1101/2020.01.27.921791

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