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Article

Genetically increased angiotensin I-converting enzyme alters peripheral and renal vascular reactivity to angiotensin II and bradykinin in mice.

American journal of physiology. Heart and circulatory physiology - 1 Feb 2018

Chollet Catherine, Placier Sandrine, Chatziantoniou Christos, Hus-Citharel Annette, Caron Nathalie, Roussel Ronan, Alhenc-Gelas François, Bouby Nadine

Abstract excerpt

Angiotensin I-converting enzyme (ACE) levels in humans are under strong genetic influence. Genetic variation in ACE has been linked to risk for and progression of cardiovascular and renal diseases. Causality has been documented in genetically modified mice, but the mechanisms underlying causality are not completely elucidated. To further document the vascular and renal consequences of a moderate genetic increase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29101168
DOI: 10.1152/ajpheart.00356.2017

Genes

ACE
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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