Article
Treprostinil reduces blood pressure and aortic inflammation in hypertension.
Clinical science (London, England : 1979) - 15 Jul 2026
AlMotairy Raghad, Ullah Md Mahbub, Blessinger Sophia, Lunel Andrew M, Fehrenbach Daniel J, Zhang Jian, Szarkowicz Carley, Ceneviva Zachary J, Wang Janey, Madhur Meena S, Shuey Megan M, Bastarache Lisa, Peebles R Stokes, Norlander Allison E
Abstract excerpt
Prostaglandin I2 (PGI2) signaling is vasoprotective. Further, PGI2 signaling exhibits immunomodulatory properties that largely promote an anti-inflammatory state. Inflammation and immune activity are associated with the development of hypertension. However, it remains unknown whether exogeneous PGI2 can restrain the immune and inflammatory responses in the context of hypertension. A phenome-wide association study...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.