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Article

Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase.

The Journal of biological chemistry - 3 Dec 2004

Bransteitter Ronda, Pham Phuong, Calabrese Peter, Goodman Myron F

Abstract excerpt

The synthesis of high affinity antibodies requires activation-induced cytidine deaminase (AID) to initiate somatic hypermutation and class-switch recombination. Here we investigate AID-catalyzed deamination of C --> U on single-stranded DNA and on actively transcribed closed circular double-stranded DNA. Mutations are initially favored at canonical WRC (W = A or T, R = A or G) somatic hypermutation hot spot...

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Source

Identifiers

PMID: 15371439
DOI: 10.1074/jbc.M408135200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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