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Single-Stranded DNA Structure and Positional Context of the Target Cytidine Determine the Enzymatic Efficiency of AID

24 Sept 2007

Abstract excerpt

Activation-induced cytidine deaminase (AID) initiates antibody diversification processes by deaminating immunoglobulin sequences. Since transcription of target genes is required for deamination in vivo and AID exclusively mutates single-stranded DNA (ssDNA) in vitro, AID has been postulated to mutate transcription bubbles. However, since ssDNA generated by transcription can assume multiple structures, it is...

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Identifiers

PMID: 17893327
DOI: 10.1128/mcb.01046-07

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Single-Stranded DNA Structure and Positional Context of the Target Cytidine Determine the Enzymatic Efficiency of AIDPMID 17893327Read ↗

AID Associates with Single-Stranded DNA with High Affinity and a Long Complex Half-Life in a Sequence-Independent MannerSemantic proximity Read ↗

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine.Semantic proximity Read ↗

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.Semantic proximity Read ↗

AID–RNA polymerase II transcription-dependent deamination of IgV DNASemantic proximity Read ↗

AID in Antibody Diversification: There and Back Again.Semantic proximity Read ↗

Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase.Semantic proximity Read ↗

Targeting of the activation-induced cytosine deaminase is strongly influenced by the sequence and structure of the targeted DNA.Semantic proximity Read ↗

Nucleic acid determinants for selective deamination of DNA over RNA by activation-induced deaminaseSemantic proximity Read ↗

Structural analysis of the activation-induced deoxycytidine deaminase required in immunoglobulin diversification.Semantic proximity Read ↗

Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro.Semantic proximity Read ↗

Transcription-targeted DNA deamination by the AID antibody diversification enzymeSemantic proximity Read ↗

Negative Supercoiling Creates Single-Stranded Patches of DNA That Are Substrates for AID–Mediated MutagenesisSemantic proximity Read ↗

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