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Reward versus Risk: DNA Cytidine Deaminases Triggering Immunity and Disease

3 Feb 2005

Abstract excerpt

The enzymatic deamination of cytosine to uracil, using the free base C, its nucleosides, and nucleotides as substrates, is an essential feature of nucleotide metabolism. However, the deamination of C and, especially, 5 methyl C on DNA is typically detrimental, causing mutations leading to serious human disease. Recently, a family of enzymes has been discovered that catalyzes the conversion of C to U on DNA and...

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PMID: 15723516
DOI: 10.1021/bi047481+

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