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Article

Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 12 Mar 2009

Chelico Linda, Pham Phuong, Goodman Myron F

Abstract excerpt

Activation-induced (cytidine) deaminase (AID) efficiently introduces multiple and diversified deaminations in immunoglobulin (Ig) variable and switch regions. Here, we review studies of AID, and the APOBEC family member, APOBEC3G, demonstrating that both enzymes introduce multiple deaminations by processive action on single-stranded DNA and that deaminations occur stochastically at hot- and cold-spot targets. In...

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Identifiers

PMID: 19022738
DOI: 10.1098/rstb.2008.0195
PMCID: PMC2660917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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