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Article

AID and Apobec3G haphazard deamination and mutational diversity.

Cellular and molecular life sciences : CMLS - 1 Sept 2013

Jaszczur Malgorzata, Bertram Jeffrey G, Pham Phuong, Scharff Matthew D, Goodman Myron F

Abstract excerpt

Activation-induced deoxycytidine deaminase (AID) and Apobec 3G (Apo3G) cause mutational diversity by initiating mutations on regions of single-stranded (ss) DNA. Expressed in B cells, AID deaminates C → U in actively transcribed immunoglobulin (Ig) variable and switch regions to initiate the somatic hypermutation (SHM) and class switch recombination (CSR) that are essential for antibody diversity. Apo3G expressed...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Source

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Identifiers

PMID: 23178850
DOI: 10.1007/s00018-012-1212-1
PMCID: PMC3600397

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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