Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.

Nature - 3 Jul 2003

Pham Phuong, Bransteitter Ronda, Petruska John, Goodman Myron F

Abstract excerpt

Activation-induced cytidine deaminase (AID) is a protein required for B cells to undergo class switch recombination and somatic hypermutation (SHM)--two processes essential for producing high-affinity antibodies. Purified AID catalyses the deamination of C to U on single-stranded (ss)DNA. Here, we show in vitro that AID-catalysed C deaminations occur preferentially on 5' WRC sequences in accord with SHM spectra...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytidine Deaminase

Share to DNA, Single-Stranded

Share to Molecular Sequence Data

Share to Mutation

Share to Somatic Hypermutation, Immunoglobulin

Share to Transcription, Genetic

Source

Identifiers

PMID: 12819663
DOI: 10.1038/nature01760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation.PMID 12819663Read ↗

Biochemical analysis of hypermutational targeting by wild type and mutant activation-induced cytidine deaminase.Semantic proximity Read ↗

Mutations in human AID differentially affect its ability to deaminate cytidine and 5-methylcytidine in ssDNA substrates in vitro.Semantic proximity Read ↗

AID in Antibody Diversification: There and Back Again.Semantic proximity Read ↗

AID and Apobec3G haphazard deamination and mutational diversity.Semantic proximity Read ↗

Mutating for Good: DNA Damage Responses During Somatic HypermutationSemantic proximity Read ↗

AID-initiated purposeful mutations in immunoglobulin genes.Semantic proximity Read ↗

Stochastic properties of processive cytidine DNA deaminases AID and APOBEC3G.Semantic proximity Read ↗

DNA substrate length and surrounding sequence affect the activation-induced deaminase activity at cytidine.Semantic proximity Read ↗

DNA flexibility can shape the preferential hypermutation of antibody genes.Semantic proximity Read ↗

AID–RNA polymerase II transcription-dependent deamination of IgV DNASemantic proximity Read ↗

Reward versus Risk: DNA Cytidine Deaminases Triggering Immunity and DiseaseSemantic proximity Read ↗

Single-Stranded DNA Structure and Positional Context of the Target Cytidine Determine the Enzymatic Efficiency of AIDSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.